Rocznila’ Almdemii Medytznq‘ w Bialymxroku - VoL 49. 2004 - Annalts Acadmu‘ae Medicae Bialosrocensîs O O I O Antnoxudants In the treatment of pabents O O wnth renal faIIure Luciak M Department of Internal Medicine and Dialysis, Medica! University of Lodi, Poland Abstract oxygen species due to their exoessive generation and impaìred efficiency of antioxidant defense mechanisms. Rena! failure is aocompanied by oxidative stress, which In renal failure patients enhanced reactive oxygen species is caused by enhanced production of reactive oxygen species production is underlain mainly by inflammation [3,4], malnutri- and impaired antioxidant defense. The suggested therapeu- tion [3], presence of endogenous stable oxidants in the uraemic tical interventions ailned at reducing oxidative stress in plasma [5]. In haemodialysis patients the additional stimulus for chronic renal failure patients are as follows: l) the use of increased free oxygen radical production can be the haemodi- bioeornpatible membranes, ultrapure dialysate, and removal alysis procedure itself [6,7].